Expression of beta 1-6-branched N-linked oligosaccharides is associated with activation in human T4 and T8 cell populations.
S Lemaire, C Derappe, JC Michalski, M Aubery… - Journal of Biological …, 1994 - ASBMB
Activation of human T lymphocytes by phorbol 12-myristate 13-acetate and leukoagglutinin
from Phaseolus vulgaris (L-PHA) results in important changes in N-glycosylation. The most
important event is the increase, in both T4 and T8 cells (especially the latter), of L-PHA+
structures characterized by beta 1-6-branching of complex-type oligosaccharides. Moreover,
the existence of a CD4-mediated increase of these beta 1-6-branched structures on
positively selected T4 cells, as compared with the negatively selected ones, suggests that …
from Phaseolus vulgaris (L-PHA) results in important changes in N-glycosylation. The most
important event is the increase, in both T4 and T8 cells (especially the latter), of L-PHA+
structures characterized by beta 1-6-branching of complex-type oligosaccharides. Moreover,
the existence of a CD4-mediated increase of these beta 1-6-branched structures on
positively selected T4 cells, as compared with the negatively selected ones, suggests that …