Since an intact membrane is required for normal cellular homeostasis, membrane repair is
essential for cell survival. Human genetic studies, combined with the development of novel
animal models and refinement of techniques to study cellular injury, have now uncovered
series of repair proteins highly relevant for human health. Many of the deficient repair
pathways manifest in skeletal muscle, where defective repair processes result in myopathies
or other forms of muscle disease. Dysferlin is a membrane-associated protein implicated in …