Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage
RM Pluta, A Dejam, G Grimes, MT Gladwin, EH Oldfield - Jama, 2005 - jamanetwork.com
ContextDelayed cerebral vasospasm causes permanent neurological deficits or death in at
least 15% of patients following otherwise successful treatment for ruptured intracranial
aneurysm. Decreased bioavailability of nitric oxide has been associated with the
development of cerebral vasospasm. ObjectiveTo determine whether infusions of nitrite will
prevent delayed cerebral vasospasm. Design, Setting, and SubjectsA total of 14
anesthetized cynomolgus monkeys had an autologous blood clot placed around the right …
least 15% of patients following otherwise successful treatment for ruptured intracranial
aneurysm. Decreased bioavailability of nitric oxide has been associated with the
development of cerebral vasospasm. ObjectiveTo determine whether infusions of nitrite will
prevent delayed cerebral vasospasm. Design, Setting, and SubjectsA total of 14
anesthetized cynomolgus monkeys had an autologous blood clot placed around the right …