[HTML][HTML] Epigenetic regulation of tumor necrosis factor α (TNFα) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 …
X Han, X Li, SC Yue, A Anandaiah, F Hashem… - Journal of Biological …, 2012 - ASBMB
Human macrophages at mucosal sites are essential targets for acute HIV infection. During
the chronic phase of infection, they are persistent reservoirs for the AIDS virus. HIV virions
gain entry into macrophages following ligation of surface CD4-CCR5 co-receptors, which
leads to the release of two copies of HIV ssRNA. These events lead to reverse transcription
and viral replication initiation. Toll-like receptors TLR7 and TLR8 recognize specific
intracellular viral ssRNA sequences, but in human alveolar macrophages, their individual …
the chronic phase of infection, they are persistent reservoirs for the AIDS virus. HIV virions
gain entry into macrophages following ligation of surface CD4-CCR5 co-receptors, which
leads to the release of two copies of HIV ssRNA. These events lead to reverse transcription
and viral replication initiation. Toll-like receptors TLR7 and TLR8 recognize specific
intracellular viral ssRNA sequences, but in human alveolar macrophages, their individual …