[HTML][HTML] Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1
S Belkaya, SE Murray, JL Eitson… - Journal of Biological …, 2013 - ASBMB
miR-185 is a microRNA (miR) that targets Bruton's tyrosine kinase in B cells, with reductions
in miR-185 linked to B cell autoantibody production. In hippocampal neurons, miR-185
targets both sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and a novel Golgi
inhibitor. This miR is haploinsufficient in 90–95% of individuals with chromosome 22q11. 2
deletion syndrome, patients who can present with immune, cardiac, and parathyroid
problems, learning disorders, and a high incidence of schizophrenia in adults. The reduced …
in miR-185 linked to B cell autoantibody production. In hippocampal neurons, miR-185
targets both sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and a novel Golgi
inhibitor. This miR is haploinsufficient in 90–95% of individuals with chromosome 22q11. 2
deletion syndrome, patients who can present with immune, cardiac, and parathyroid
problems, learning disorders, and a high incidence of schizophrenia in adults. The reduced …