[HTML][HTML] p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation
Although p53 is frequently mutated in human cancers, about 80% of human melanomas
retain wild-type p53. Here we report that PHGDH, the key metabolic enzyme that catalyzes
the rate-limiting step of the serine biosynthesis pathway, is a target of p53 in human
melanoma cells. p53 suppresses PHGDH expression and inhibits de novo serine
biosynthesis. Notably, upon serine starvation, p53-mediated cell death is enhanced
dramatically in response to Nutlin-3 treatment. Moreover, PHGDH has been found recently …
retain wild-type p53. Here we report that PHGDH, the key metabolic enzyme that catalyzes
the rate-limiting step of the serine biosynthesis pathway, is a target of p53 in human
melanoma cells. p53 suppresses PHGDH expression and inhibits de novo serine
biosynthesis. Notably, upon serine starvation, p53-mediated cell death is enhanced
dramatically in response to Nutlin-3 treatment. Moreover, PHGDH has been found recently …
