[HTML][HTML] Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse …
P Ramadoss, BJ Abraham, L Tsai, Y Zhou… - Journal of Biological …, 2014 - ASBMB
Triiodothyronine (T3) regulates key metabolic processes in the liver through the thyroid
hormone receptor, TRβ1. However, the number of known target genes directly regulated by
TRβ1 is limited, and the mechanisms by which positive and especially negative
transcriptional regulation occur are not well understood. To characterize the TRβ1 cistrome
in vivo, we expressed a biotinylated TRβ1 in hypo-and hyperthyroid mouse livers, used ChIP-
seq to identify genomic TRβ1 targets, and correlated these data with gene expression …
hormone receptor, TRβ1. However, the number of known target genes directly regulated by
TRβ1 is limited, and the mechanisms by which positive and especially negative
transcriptional regulation occur are not well understood. To characterize the TRβ1 cistrome
in vivo, we expressed a biotinylated TRβ1 in hypo-and hyperthyroid mouse livers, used ChIP-
seq to identify genomic TRβ1 targets, and correlated these data with gene expression …