Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted …
JS Ross, K Wang, JV Rand, CE Sheehan… - The American journal …, 2014 - journals.lww.com
We hypothesized that next-generation sequencing could reveal actionable genomic
alterations (GAs) and potentially expand treatment options for patients with advanced
adenoid cystic carcinoma (ACC). Genomic profiling using next-generation sequencing was
performed on hybridization-captured, adapter ligation libraries derived from 28 relapsed and
metastatic formalin-fixed paraffin-embedded ACC. The 3230 exons of 182 cancer-related
genes and 37 introns of 14 genes frequently rearranged in cancer were fully sequenced …
alterations (GAs) and potentially expand treatment options for patients with advanced
adenoid cystic carcinoma (ACC). Genomic profiling using next-generation sequencing was
performed on hybridization-captured, adapter ligation libraries derived from 28 relapsed and
metastatic formalin-fixed paraffin-embedded ACC. The 3230 exons of 182 cancer-related
genes and 37 introns of 14 genes frequently rearranged in cancer were fully sequenced …