The varied roles of notch in cancer
JC Aster, WS Pear, SC Blacklow - Annual Review of Pathology …, 2017 - annualreviews.org
JC Aster, WS Pear, SC Blacklow
Annual Review of Pathology: Mechanisms of Disease, 2017•annualreviews.orgNotch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on
signal dose and cell context. Here, after briefly reviewing new insights into physiologic
mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that
contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in
cancer, focusing on cell autonomous activities that may be either oncogenic or tumor …
pathway, but outcomes produced by Notch signaling are remarkably varied depending on
signal dose and cell context. Here, after briefly reviewing new insights into physiologic
mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that
contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in
cancer, focusing on cell autonomous activities that may be either oncogenic or tumor …
Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.
Annual Reviews