[HTML][HTML] Characterization of β-R1, a gene that is selectively induced by interferon β (IFN-β) compared with IFN-α

MRS Rani, GR Foster, S Leung, D Leaman… - Journal of Biological …, 1996 - ASBMB
We report preliminary characterization of a gene designated β-R1, which is selectively
expressed in response to interferon β (IFN-β) compared with IFN-α. In human astrocytoma
cells, β-R1 was induced to an equivalent extent by 10 IU/mL IFN-β or 2500 IU/mL IFN-α2. To
address the mechanism of this differential response, we analyzed induction of the β-R1
gene in fibrosarcoma cells and derivative mutant cells lacking components required for
signaling by type I IFNs. β-R1 was readily induced by IFN-β in the parental 2fTGH cell line …