[HTML][HTML] Impaired multimerization of human adiponectin mutants associated with diabetes: molecular structure and multimer formation of adiponectin
H Waki, T Yamauchi, J Kamon, Y Ito, S Uchida… - Journal of Biological …, 2003 - ASBMB
Adiponectin is an adipocyte-derived hormone, which has been shown to play important
roles in the regulation of glucose and lipid metabolism. Eight mutations in human
adiponectin have been reported, some of which were significantly related to diabetes and
hypoadiponectinemia, but the molecular mechanisms of decreased plasma levels and
impaired action of adiponectin mutants were not clarified. Adiponectin structurally belongs to
the complement 1q family and is known to form a characteristic homomultimer. Herein, we …
roles in the regulation of glucose and lipid metabolism. Eight mutations in human
adiponectin have been reported, some of which were significantly related to diabetes and
hypoadiponectinemia, but the molecular mechanisms of decreased plasma levels and
impaired action of adiponectin mutants were not clarified. Adiponectin structurally belongs to
the complement 1q family and is known to form a characteristic homomultimer. Herein, we …