Exosomes secreted by normal and cancer cells carry and deliver a variety of molecules. To
date, mechanisms referring to tumor exosome trafficking, including release and cell-cell
transmission, have not been described. To gain insight into this, exosomes purified from
metastatic melanoma cell medium were labeled with a lipid fluorescent probe, R18, and
analyzed by spectrofluorometry and confocal microscopy. A low pH condition is a hallmark
of tumor malignancy, potentially influencing exosome release and uptake by cancer cells …