Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk
MC Amato, C Giordano, M Galia, A Criscimanna… - Diabetes …, 2010 - Am Diabetes Assoc
Diabetes care, 2010•Am Diabetes Assoc
OBJECTIVE To individuate a novel sex-specific index, based on waist circumference, BMI,
triglycerides, and HDL cholesterol, indirectly expressing visceral fat function. RESEARCH
DESIGN AND METHODS Visceral adiposity index (VAI) was first modeled on 315 nonobese
healthy subjects. Using two multiple logistic regression models, VAI was retrospectively
validated in 1,498 primary care patients in comparison to classical cardio-and
cerebrovascular risk factors. RESULTS All components of metabolic syndrome increased …
triglycerides, and HDL cholesterol, indirectly expressing visceral fat function. RESEARCH
DESIGN AND METHODS Visceral adiposity index (VAI) was first modeled on 315 nonobese
healthy subjects. Using two multiple logistic regression models, VAI was retrospectively
validated in 1,498 primary care patients in comparison to classical cardio-and
cerebrovascular risk factors. RESULTS All components of metabolic syndrome increased …
OBJECTIVE
To individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function.
RESEARCH DESIGN AND METHODS
Visceral adiposity index (VAI) was first modeled on 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio- and cerebrovascular risk factors.
RESULTS
All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (odd ratio [OR] 2.45; 95% CI 1.52–3.95; P < 0.001) and cerebrovascular (1.63; 1.06–2.50; P = 0.025) events. VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (Rs = −0.721; P < 0.001). By contrast, no correlations were found for waist circumference and BMI.
CONCLUSIONS
Our study suggests VAI is a valuable indicator of “visceral adipose function” and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.
Am Diabetes Assoc