Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal
relationships remains uncertain. Objective To test the association of a polygenic risk score
for waist-to-hip ratio (WHR) adjusted for body mass index (BMI), a measure of abdominal
adiposity, with type 2 diabetes and CHD through the potential intermediates of blood lipids,
blood pressure, and glycemic phenotypes. Design, Setting, and Participants A polygenic risk …