[PDF][PDF] Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure

M Liesa, OS Shirihai - Cell metabolism, 2013 - cell.com
Cell metabolism, 2013cell.com
Mitochondrial fusion, fission, and mitophagy form an essential axis of mitochondrial quality
control. However, quality control might not be the only task carried out by mitochondrial
dynamics. Recent studies link mitochondrial dynamics to the balance between energy
demand and nutrient supply, suggesting changes in mitochondrial architecture as a
mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected
or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and …
Mitochondrial fusion, fission, and mitophagy form an essential axis of mitochondrial quality control. However, quality control might not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placement of bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics might provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.
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