[HTML][HTML] Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells

H Kanamori, S Krieg, C Mao, VA Di Pippo… - Journal of Biological …, 2000 - ASBMB
Although liver is an estrogen target tissue, the number of hepatic genes known to be directly
induced by estrogen is very small. We identified proteinase inhibitor 9, or PI-9, as being
rapidly and strongly induced by estrogen in an estrogen receptor-positive human liver cell
line (HepG2-ER7). Since PI-9 mRNA was also induced by estrogen in a human liver biopsy
sample, PI-9 is a genuine estrogen-regulated human gene. PI-9 is a potent inhibitor of
granzyme B and of granzyme B-mediated apoptosis. Estrogens induced PI-9 mRNA within 2 …