6-Hydroxy-dopamine induced degeneration of central monoamine neurons
U Ungerstedt - European journal of pharmacology, 1968 - Elsevier
U Ungerstedt
European journal of pharmacology, 1968•ElsevierIntracerebral injection of 6-hydroxy-dopamine induced degeneration of central dopamine
and noradrenaline neurons. Injection into the substantia nigra produced an anterograde
degeneration of the whole nigro-neostriatal dopamine neuron system. This was associated
with marked motor disturbances. It is suggested that intracerebral administration of 6-
hydroxy-dopamine may be used as a tool for anatomical and functional studies on central
monoamine neurons.
and noradrenaline neurons. Injection into the substantia nigra produced an anterograde
degeneration of the whole nigro-neostriatal dopamine neuron system. This was associated
with marked motor disturbances. It is suggested that intracerebral administration of 6-
hydroxy-dopamine may be used as a tool for anatomical and functional studies on central
monoamine neurons.
Abstract
Intracerebral injection of 6-hydroxy-dopamine induced degeneration of central dopamine and noradrenaline neurons. Injection into the substantia nigra produced an anterograde degeneration of the whole nigro-neostriatal dopamine neuron system. This was associated with marked motor disturbances. It is suggested that intracerebral administration of 6-hydroxy-dopamine may be used as a tool for anatomical and functional studies on central monoamine neurons.
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