[HTML][HTML] Fibroblast growth factor-binding protein is a novel partner for perlecan protein core
M Mongiat, J Otto, R Oldershaw, F Ferrer… - Journal of Biological …, 2001 - ASBMB
Perlecan, a widespread heparan sulfate proteoglycan, functions as a bioactive reservoir for
growth factors by stabilizing them against misfolding or proteolysis. These factors, chiefly
members of the fibroblast growth factor (FGF) gene family, are coupled to the N-terminal
heparan sulfate chains, which augment high affinity binding and receptor activation.
However, rather little is known about biological partners of the protein core. The major goal
of this study was to identify novel proteins that interact with the protein core of perlecan …
growth factors by stabilizing them against misfolding or proteolysis. These factors, chiefly
members of the fibroblast growth factor (FGF) gene family, are coupled to the N-terminal
heparan sulfate chains, which augment high affinity binding and receptor activation.
However, rather little is known about biological partners of the protein core. The major goal
of this study was to identify novel proteins that interact with the protein core of perlecan …