[HTML][HTML] Interleukin-1 is associated with inflammation and structural lung disease in young children with cystic fibrosis
ST Montgomery, AS Dittrich, LW Garratt… - Journal of Cystic …, 2018 - Elsevier
Journal of Cystic Fibrosis, 2018•Elsevier
Background Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic
fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling,
neutrophilic inflammation and structural lung changes in children with CF. Methods
Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α,
IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to
structural lung changes observed on chest computed tomography (CT) scans. Results IL-1α …
fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling,
neutrophilic inflammation and structural lung changes in children with CF. Methods
Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α,
IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to
structural lung changes observed on chest computed tomography (CT) scans. Results IL-1α …
Background
Little is known about the role of interleukin (IL)-1 in the pathogenesis of cystic fibrosis (CF) lung disease. This study investigated the relationship between IL-1 signalling, neutrophilic inflammation and structural lung changes in children with CF.
Methods
Bronchoalveolar lavage fluid (BALf) from 102 children with CF were used to determine IL-1α, IL-1β, IL-8 levels and neutrophil elastase (NE) activity, which were then correlated to structural lung changes observed on chest computed tomography (CT) scans.
Results
IL-1α and IL-1β were detectable in BAL in absence of infection, increased in the presence of bacterial infection and correlated with IL-8 (p < 0.0001), neutrophils (p < 0.0001) and NE activity (p < 0.01 and p < 0.001). IL-1α had the strongest association with structural lung disease (p < 0.01) in the absence of infection (uninfected: p < 0.01 vs. infected: p = 0.122).
Conclusion
Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target.
Elsevier