Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis
S Thamilselvan, RL Hackett, SR Khan - The Journal of urology, 1997 - Elsevier
PURPOSE: To determine if lipid peroxidation plays a role in renal injury associated with
experimental nephrolithiasis. MATERIALS AND METHODS: Hyperoxaluria was produced in
rats by ethylene glycol in drinking water. At 15, 30 and 60 days of treatment, urinary oxalate,
lipid peroxide, calcium oxalate crystals, enzymes and tissue lipid peroxide were measured.
RESULTS: Urinary oxalate increased significantly at all time periods and was associated
with crystalluria. Lipid peroxides in kidney tissue and urine increased at all time periods …
experimental nephrolithiasis. MATERIALS AND METHODS: Hyperoxaluria was produced in
rats by ethylene glycol in drinking water. At 15, 30 and 60 days of treatment, urinary oxalate,
lipid peroxide, calcium oxalate crystals, enzymes and tissue lipid peroxide were measured.
RESULTS: Urinary oxalate increased significantly at all time periods and was associated
with crystalluria. Lipid peroxides in kidney tissue and urine increased at all time periods …