[HTML][HTML] Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer
The insulin receptor exists as two isoforms, IR-A and IR-B, which result from alternative
splicing of exon 11 in the primary transcript. These two isoforms show a cell-specific
distribution, and their relative proportions also vary during development, aging, and in
different disease states. We have previously demonstrated that both intron 10 and the
alternatively spliced exon 11 contain regulatory sequences that affect insulin receptor
splicing both positively and negatively and that these sequences bind the serine/arginine …
splicing of exon 11 in the primary transcript. These two isoforms show a cell-specific
distribution, and their relative proportions also vary during development, aging, and in
different disease states. We have previously demonstrated that both intron 10 and the
alternatively spliced exon 11 contain regulatory sequences that affect insulin receptor
splicing both positively and negatively and that these sequences bind the serine/arginine …