IRS1‐ rs10498210 G/A and CCR5‐59029 A/G polymorphisms in patients with type 2 diabetes in Kurdistan
F Keshavarzi, S Golsheh - Molecular Genetics & Genomic …, 2019 - Wiley Online Library
F Keshavarzi, S Golsheh
Molecular Genetics & Genomic Medicine, 2019•Wiley Online LibraryBackground The insulin receptor substrate 1 (IRS 1) is a critical factor in the signaling
pathway for insulin, and mutations in this gene have been reported, which contribute to the
ability to develop type 2 diabetes. The polymorphisms in the promoter region of C‐C motif
chemokine receptor5 (CCR 5) are also being studied as candidates for susceptibility to
develop type 2 diabetes. The aim of the current study was to determine the relationship
between IRS 1 and CCR 5 polymorphisms with type 2 diabetes in the Kurdistan population …
pathway for insulin, and mutations in this gene have been reported, which contribute to the
ability to develop type 2 diabetes. The polymorphisms in the promoter region of C‐C motif
chemokine receptor5 (CCR 5) are also being studied as candidates for susceptibility to
develop type 2 diabetes. The aim of the current study was to determine the relationship
between IRS 1 and CCR 5 polymorphisms with type 2 diabetes in the Kurdistan population …
Background
The insulin receptor substrate 1 (IRS1) is a critical factor in the signaling pathway for insulin, and mutations in this gene have been reported, which contribute to the ability to develop type 2 diabetes. The polymorphisms in the promoter region of C‐C motif chemokine receptor5 (CCR5) are also being studied as candidates for susceptibility to develop type 2 diabetes. The aim of the current study was to determine the relationship between IRS1 and CCR5 polymorphisms with type 2 diabetes in the Kurdistan population.
Methods
Genomic DNA was isolated from the blood by salt extraction method and the polymorphisms were examined using Restriction Fragment Length Polymorphism (RFLP) method.
Results
The results of current study indicated that the frequency of AA genotype in type 2 diabetic patients in both CCR5 (OR = 2.9, p = 0.04) and IRS1 (OR = 3.3, p = 0.036) were significantly more than controls.
Conclusion
According to the results of this study, the presence of AA genotype in both CCR5 and IRS1 is associated with type 2 diabetes. There was no significant association between AG or GG genotypes with type 2 diabetes.
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