[PDF][PDF] Progression through the RNA polymerase II CTD cycle
S Buratowski - Molecular cell, 2009 - cell.com
S Buratowski
Molecular cell, 2009•cell.comThe C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic
phosphorylation during transcription, and the different phosphorylation patterns that
predominate at each stage of transcription recruit the appropriate set of mRNA-processing
and histone-modifying factors. Recent papers help to explain how the changes in CTD
phosphorylation pattern are linked to the progression from initiation through elongation to
termination.
phosphorylation during transcription, and the different phosphorylation patterns that
predominate at each stage of transcription recruit the appropriate set of mRNA-processing
and histone-modifying factors. Recent papers help to explain how the changes in CTD
phosphorylation pattern are linked to the progression from initiation through elongation to
termination.
Summary
The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of transcription recruit the appropriate set of mRNA-processing and histone-modifying factors. Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination.
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