[HTML][HTML] Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6

K Yanagida, K Masago, H Nakanishi, Y Kihara… - Journal of Biological …, 2009 - ASBMB
p2y5 is an orphan G protein-coupled receptor that is closely related to the fourth
lysophosphatidic acid (LPA) receptor, LPA 4. Here we report that p2y5 is a novel LPA
receptor coupling to the G 13-Rho signaling pathway." LPA receptor-null" RH7777 and B103
cells exogenously expressing p2y5 showed [3 H] LPA binding, LPA-induced [35 S]
guanosine 5′-3-O-(thio) triphosphate binding, Rho-dependent alternation of cellular
morphology, and G s/13 chimeric protein-mediated cAMP accumulation. LPA-induced …