Exosomes secreted from bone marrow-derived mesenchymal stem cells protect the intestines from experimental necrotizing enterocolitis
TM Rager, JK Olson, Y Zhou, Y Wang… - Journal of pediatric …, 2016 - Elsevier
Purpose Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Bone
marrow-derived mesenchymal stem cells (BM-MSCs) can protect the intestines from NEC.
Exosomes are nanoparticle-sized vesicles with important cell signaling capabilities. The
objective of this study was to determine whether BM-MSC-derived exosomes can prevent
NEC. Methods Rat pups were either breast fed (Group 1) or subjected to experimental NEC
and randomized to receive either no treatment (Group 2) or an intraperitoneal (IP) injection …
marrow-derived mesenchymal stem cells (BM-MSCs) can protect the intestines from NEC.
Exosomes are nanoparticle-sized vesicles with important cell signaling capabilities. The
objective of this study was to determine whether BM-MSC-derived exosomes can prevent
NEC. Methods Rat pups were either breast fed (Group 1) or subjected to experimental NEC
and randomized to receive either no treatment (Group 2) or an intraperitoneal (IP) injection …