GLP-1 influences food and drug reward
MR Hayes, HD Schmidt - Current opinion in behavioral sciences, 2016 - Elsevier
Highlights•GLP-1 receptor activation will influence multiple reward-related
behaviors.•Obesity and maladaptive reward behaviors can be treated by targeting reward
nuclei.•Current GLP-1 analogs can be used to treat obesity and drug/alcohol
addiction.•Current GLP-1 analogs are limited in effect size due to side effects.Natural
rewards, including food, water, sleep and social interactions, are required to sustain life. The
neural substrates that regulate the reinforcing effects of these behaviors are also the same …
behaviors.•Obesity and maladaptive reward behaviors can be treated by targeting reward
nuclei.•Current GLP-1 analogs can be used to treat obesity and drug/alcohol
addiction.•Current GLP-1 analogs are limited in effect size due to side effects.Natural
rewards, including food, water, sleep and social interactions, are required to sustain life. The
neural substrates that regulate the reinforcing effects of these behaviors are also the same …