Control of gluconeogenesis in liver: II. Effects of glucagon, catecholamines, and adenosine 3′, 5′-monophosphate on gluconeogenesis in the perfused rat liver
JH Exton, CR Park - Journal of Biological Chemistry, 1968 - ASBMB
Glucagon, epinephrine, norepinephrine, and cyclic AMP stimulated gluconeogenesis from
lactate in perfused livers from fasted and fed rats. The stimulation was most marked when
these agents were added to livers from fasted rats in which gluconeogenesis had become
partially inactive during a preliminary perfusion without substrate. It is suggested that
inactivation is consequent to the degradation of endogenous glucagon and catecholamines.
Inactivation could be prevented by high levels of lactate. On a molar basis, glucagon was …
lactate in perfused livers from fasted and fed rats. The stimulation was most marked when
these agents were added to livers from fasted rats in which gluconeogenesis had become
partially inactive during a preliminary perfusion without substrate. It is suggested that
inactivation is consequent to the degradation of endogenous glucagon and catecholamines.
Inactivation could be prevented by high levels of lactate. On a molar basis, glucagon was …