[HTML][HTML] Requirement for annexin A1 in plasma membrane repair

AK McNeil, U Rescher, V Gerke, PL McNeil - Journal of biological chemistry, 2006 - ASBMB
Ca 2+ entering a cell through a torn or disrupted plasma membrane rapidly triggers a
combination of homotypic and exocytotic membrane fusion events. These events serve to
erect a reparative membrane patch and then anneal it to the defect site. Annexin A1 is a
cytosolic protein that, when activated by micromolar Ca 2+, binds to membrane
phospholipids, promoting membrane aggregation and fusion. We demonstrate here that an
annexin A1 function-blocking antibody, a small peptide competitor, and a dominant-negative …