Annexins are soluble proteins that bind to biological membranes in a Ca2+-dependent
manner. Annexin-A6 (AnxA6) is unique in the annexin family as it consists of the repeat of
two annexin core modules, while all other annexins consist of a single module. AnxA6 has
been proposed to participate in various membrane-related processes, including endocytosis
and exocytosis, yet the molecular mechanism of association of AnxA6 with biological
membranes, especially its ability to aggregate membranes, is still unclear. To address this …