Association of genetic variants related to gluteofemoral vs abdominal fat distribution with type 2 diabetes, coronary disease, and cardiovascular risk factors
Importance Body fat distribution, usually measured using waist-to-hip ratio (WHR), is an
important contributor to cardiometabolic disease independent of body mass index (BMI).
Whether mechanisms that increase WHR via lower gluteofemoral (hip) or via higher
abdominal (waist) fat distribution affect cardiometabolic risk is unknown. Objective To
identify genetic variants associated with higher WHR specifically via lower gluteofemoral or
higher abdominal fat distribution and estimate their association with cardiometabolic risk …
important contributor to cardiometabolic disease independent of body mass index (BMI).
Whether mechanisms that increase WHR via lower gluteofemoral (hip) or via higher
abdominal (waist) fat distribution affect cardiometabolic risk is unknown. Objective To
identify genetic variants associated with higher WHR specifically via lower gluteofemoral or
higher abdominal fat distribution and estimate their association with cardiometabolic risk …