[HTML][HTML] Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon …
H Jia, C Thelwell, P Dilger, C Bird, S Daniels… - Thrombosis research, 2018 - Elsevier
Introduction Interferon (IFN)-α and IFN-β approved for treatment of chronic hepatitis C viral
infection and multiple sclerosis respectively have been linked to thrombotic microangiopathy
(TMA) affecting renal function. Since the molecular mechanisms underlying this severe
complication remain largely unclear, we aimed to investigate whether IFN affects directly in
vitro endothelial cell functions associated with angiogenesis and blood haemostasis, as well
as endothelial cell-derived vasodilators of nitric oxide (NO) and prostacyclin. Methods …
infection and multiple sclerosis respectively have been linked to thrombotic microangiopathy
(TMA) affecting renal function. Since the molecular mechanisms underlying this severe
complication remain largely unclear, we aimed to investigate whether IFN affects directly in
vitro endothelial cell functions associated with angiogenesis and blood haemostasis, as well
as endothelial cell-derived vasodilators of nitric oxide (NO) and prostacyclin. Methods …