[HTML][HTML] Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1
Autotaxin (ATX) is a tumor cell motility-stimulating factor originally isolated from melanoma
cell supernatant that has been implicated in regulation of invasive and metastatic properties
of cancer cells. Recently, we showed that ATX is identical to lysophospholipase D, which
converts lysophosphatidylcholine to a potent bioactive phospholipid mediator,
lysophosphatidic acid (LPA), raising the possibility that autocrine or paracrine production of
LPA by ATX contributes to tumor cell motility. Here we demonstrate that LPA and ATX …
cell supernatant that has been implicated in regulation of invasive and metastatic properties
of cancer cells. Recently, we showed that ATX is identical to lysophospholipase D, which
converts lysophosphatidylcholine to a potent bioactive phospholipid mediator,
lysophosphatidic acid (LPA), raising the possibility that autocrine or paracrine production of
LPA by ATX contributes to tumor cell motility. Here we demonstrate that LPA and ATX …