Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

RM Hudziak, J Schlessinger… - Proceedings of the …, 1987 - National Acad Sciences
RM Hudziak, J Schlessinger, A Ullrich
Proceedings of the National Academy of Sciences, 1987National Acad Sciences
The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the
epidermal growth factor receptor. Recently it was found to be amplified in about 30% of
primary human breast malignancies. In experiments designed to assess the role of the
HER2 gene in oncogenesis, we found that overexpression of unaltered HER2 coding
sequences in NIH 3T3 cells resulted in cellular transformation and tumorigenesis.
The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unaltered HER2 coding sequences in NIH 3T3 cells resulted in cellular transformation and tumorigenesis.
National Acad Sciences