Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-
tissue tumors. While significant advances have been made in improving outcomes of
patients with localized pediatric sarcomas since the addition of systemic chemotherapy to
local control many decades ago, outcomes for patients with metastatic and relapsed
sarcoma remain poor with few novel therapeutics identified to date. With the advent of new
technologies to study cancer genomes, transcriptomes and epigenomes, our understanding …