Inhibition of allergic encephalomyelitis by the iron chelating agent desferrioxamine: differential effect depending on type of sensitizing encephalitogen
DO Willenborg, NA Bowern, G Danta… - Journal of …, 1988 - Elsevier
Induction of experimental allergic encephalomyelitis (EAE) in Lewis rats by injection of
guinea pig (GP) spinal cord homogenate (SCH) plus adjuvant (SCH-CFA) can be inhibited
by treatment with the iron chelating agent desferrioxamine (DFOM). Interestingly, induction
of EAE with purified myelin basic protein (BP-CFA) is not inhibited with DFOM. This
dichotomy does not appear to be due to any quantitative differences in the two inocula since
minimal clinical EAE produced by threshold levels of BP is not inhibited with DFOM. Passive …
guinea pig (GP) spinal cord homogenate (SCH) plus adjuvant (SCH-CFA) can be inhibited
by treatment with the iron chelating agent desferrioxamine (DFOM). Interestingly, induction
of EAE with purified myelin basic protein (BP-CFA) is not inhibited with DFOM. This
dichotomy does not appear to be due to any quantitative differences in the two inocula since
minimal clinical EAE produced by threshold levels of BP is not inhibited with DFOM. Passive …