Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties
SC Satchell, KL Anderson… - Journal of the American …, 2004 - journals.lww.com
Normal glomerular filtration depends on the combined properties of the three layers of
glomerular capillary wall: glomerular endothelial cells (GEnC), basement membrane, and
podocytes. Podocytes produce endothelial factors, including angiopoietin 1 (ang1), and
vascular endothelial growth factor (VEGF), whereas GEnC express their respective
receptors Tie2 and VEGFR2 in vivo. As ang1 acts to maintain the endothelium in other
vascular beds, regulating some actions of VEGF, these observations suggest a mechanism …
glomerular capillary wall: glomerular endothelial cells (GEnC), basement membrane, and
podocytes. Podocytes produce endothelial factors, including angiopoietin 1 (ang1), and
vascular endothelial growth factor (VEGF), whereas GEnC express their respective
receptors Tie2 and VEGFR2 in vivo. As ang1 acts to maintain the endothelium in other
vascular beds, regulating some actions of VEGF, these observations suggest a mechanism …