Soluble urokinase-type plasminogen activator receptor in black Americans with CKD
Results At baseline, the median suPAR was 4462 pg/ml, mean measured GFR was 46
ml/min per 1.73 m 2, and median 24-hour urine protein-to-creatinine ratio was 80 mg/g. After
controlling for baseline demographics, randomization arm, GFR, proteinuria, APOL1 risk
status, and clinical risk factors, there was a 1.26-times higher risk for CKD progression per
SD higher baseline log-transformed suPAR (hazard ratio [HR], 1.26; 95% confidence
interval [95% CI], 1.11 to 1.43; P< 0.001). Higher suPAR was also independently associated …
ml/min per 1.73 m 2, and median 24-hour urine protein-to-creatinine ratio was 80 mg/g. After
controlling for baseline demographics, randomization arm, GFR, proteinuria, APOL1 risk
status, and clinical risk factors, there was a 1.26-times higher risk for CKD progression per
SD higher baseline log-transformed suPAR (hazard ratio [HR], 1.26; 95% confidence
interval [95% CI], 1.11 to 1.43; P< 0.001). Higher suPAR was also independently associated …