[PDF][PDF] Relationship Between MYCN Copy Number and Expression in Rhabdomyosarcomas and Correlation With Adverse Prognosis in the Alveolar Subtype
D Williamson, YJ Lu, T Gordon, R Sciot… - Journal of Clinical …, 2005 - researchgate.net
Journal of Clinical Oncology, 2005•researchgate.net
Purpose Amplification of the transcription factor MYCN is an important molecular diagnostic
tool in stratifying treatment for neuroblastoma. Increased copy number and overexpression
of MYCN in the pediatric cancer rhabdomyosarcoma has been described in a number of
small studies with conflicting conclusions about its association with clinicopathologic
characteristics. We aimed to study the phenomenon in the largest series to date.
tool in stratifying treatment for neuroblastoma. Increased copy number and overexpression
of MYCN in the pediatric cancer rhabdomyosarcoma has been described in a number of
small studies with conflicting conclusions about its association with clinicopathologic
characteristics. We aimed to study the phenomenon in the largest series to date.
Purpose
Amplification of the transcription factor MYCN is an important molecular diagnostic tool in stratifying treatment for neuroblastoma. Increased copy number and overexpression of MYCN in the pediatric cancer rhabdomyosarcoma has been described in a number of small studies with conflicting conclusions about its association with clinicopathologic characteristics. We aimed to study the phenomenon in the largest series to date.
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