[HTML][HTML] IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo
Y Nakanishi, T Sato, K Takahashi, T Ohteki - Mucosal immunology, 2018 - Elsevier
Colonic macrophages induce pathogenic inflammation against commensal bacteria, leading
to inflammatory bowel disease (IBD). Although the ontogeny of colonic macrophages has
been well studied in the past decade, how macrophages gain colitogenic properties during
the development of colitis is unknown. Using a chemically induced colitis model, we showed
that accumulated Ly6C+ cells consisting of inflammatory monocytes and inflammatory
macrophages strongly expressed representative colitogenic mediators such as tumor …
to inflammatory bowel disease (IBD). Although the ontogeny of colonic macrophages has
been well studied in the past decade, how macrophages gain colitogenic properties during
the development of colitis is unknown. Using a chemically induced colitis model, we showed
that accumulated Ly6C+ cells consisting of inflammatory monocytes and inflammatory
macrophages strongly expressed representative colitogenic mediators such as tumor …