[HTML][HTML] Disrupting neuronal transmission: mechanism of DBS?

S Chiken, A Nambu - Frontiers in systems neuroscience, 2014 - frontiersin.org
S Chiken, A Nambu
Frontiers in systems neuroscience, 2014frontiersin.org
Applying high-frequency stimulation (HFS) to deep brain structure, known as deep brain
stimulation (DBS), has now been recognized an effective therapeutic option for a wide range
of neurological and psychiatric disorders. DBS targeting the basal ganglia thalamo-cortical
loop, especially the internal segment of the globus pallidus (GPi), subthalamic nucleus
(STN) and thalamus, has been widely employed as a successful surgical therapy for
movement disorders, such as Parkinson's disease, dystonia and tremor. However, the …
Applying high-frequency stimulation (HFS) to deep brain structure, known as deep brain stimulation (DBS), has now been recognized an effective therapeutic option for a wide range of neurological and psychiatric disorders. DBS targeting the basal ganglia thalamo-cortical loop, especially the internal segment of the globus pallidus (GPi), subthalamic nucleus (STN) and thalamus, has been widely employed as a successful surgical therapy for movement disorders, such as Parkinson’s disease, dystonia and tremor. However, the neurophysiological mechanism underling the action of DBS remains unclear and is still under debate: does DBS inhibit or excite local neuronal elements? In this review, we will examine this question and propose the alternative interpretation: DBS dissociates inputs and outputs, resulting in disruption of abnormal signal transmission.
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