[HTML][HTML] Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset
AK Chauhan, C Chen, TL Moore, RJ DiPaolo - Journal of Biological …, 2015 - ASBMB
Whether or not CD4+ T-cells express low affinity receptor FcγRIIIa (CD16a) in disease
pathology has not been examined in great detail. In this study, we show that a subset of
activated CD4+ T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune
complexes (ICs) in human CD4+ T-cells produced co-stimulatory signal like CD28 that
triggered IFN-γ production. The induced expression of FcγRIIIa on CD4+ helper T-cells is an
important finding since these receptors via ITAM contribute to intracellular signaling. The …
pathology has not been examined in great detail. In this study, we show that a subset of
activated CD4+ T-cells in humans express FcγRIIIa. The ligation of FcγRIIIa by immune
complexes (ICs) in human CD4+ T-cells produced co-stimulatory signal like CD28 that
triggered IFN-γ production. The induced expression of FcγRIIIa on CD4+ helper T-cells is an
important finding since these receptors via ITAM contribute to intracellular signaling. The …