[PDF][PDF] IL-13 Ra2-mediated interleukin-13 neutralization represses in vivo progressive growth of a T-cell lymphoma
Dalton's lymphoma (DL) is a T-cell lymphoma of spontaneous origin, characterized by highly
invasive and malignant nature, killing the host in a very short period of life span. DL-bearing
host is reflected by very high titer of IL-13 in serum. Therefore, we hypothesized that over
expression of IL-13 may greatly affect the growth of DL-cells in a tumor-bearing host. In this
study, to assess the involvement of IL-13 in DL-cell progression, we have blocked the IL-13
activity/signalling by the systemic delivery of non-signaling decoy receptor IL-13 Ra2, and IL …
invasive and malignant nature, killing the host in a very short period of life span. DL-bearing
host is reflected by very high titer of IL-13 in serum. Therefore, we hypothesized that over
expression of IL-13 may greatly affect the growth of DL-cells in a tumor-bearing host. In this
study, to assess the involvement of IL-13 in DL-cell progression, we have blocked the IL-13
activity/signalling by the systemic delivery of non-signaling decoy receptor IL-13 Ra2, and IL …