Mammalian MAP kinase signalling cascades

L Chang, M Karin - Nature, 2001 - nature.com
L Chang, M Karin
Nature, 2001nature.com
Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes,
unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research
concentrated on defining the components and organization of MAPK signalling cascades,
but recent studies have begun to shed light on the physiological functions of these cascades
in the control of gene expression, cell proliferation and programmed cell death.
Abstract
Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.
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