[HTML][HTML] D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density …
To test the hypothesis that intestine is a major site of action for D-4F, LDLR−/− mice were fed
a Western diet (WD) and administered the peptide subcutaneously (SQ) or orally. Plasma
and liver D-4F levels were 298-fold and 96-fold higher, respectively, after SQ administration,
whereas peptide levels in small intestine only varied by 1.66±0.33-fold. Levels of
metabolites of arachidonic and linoleic acids known to bind with high affinity to D-4F were
significantly reduced in intestine, liver and hepatic bile to a similar degree whether …
a Western diet (WD) and administered the peptide subcutaneously (SQ) or orally. Plasma
and liver D-4F levels were 298-fold and 96-fold higher, respectively, after SQ administration,
whereas peptide levels in small intestine only varied by 1.66±0.33-fold. Levels of
metabolites of arachidonic and linoleic acids known to bind with high affinity to D-4F were
significantly reduced in intestine, liver and hepatic bile to a similar degree whether …