COX-2 and PGE2-dependent immunomodulation in breast cancer
EP Chen, EM Smyth - Prostaglandins & other lipid mediators, 2011 - Elsevier
COX-derived prostanoids play multiple roles in inflammation and cancer. This review
highlights research examining COX-2 and PGE2-dependent regulation of immune cell
polarization and function within the tumor microenvironment, particularly as it pertains to
breast cancer. Appreciating PGE2-mediated immunomodulation is important in
understanding how tumors evade immune surveillance by re-educating infiltrating
inflammatory and immune cells to support tumorigenesis. Elucidation of the multiple and …
highlights research examining COX-2 and PGE2-dependent regulation of immune cell
polarization and function within the tumor microenvironment, particularly as it pertains to
breast cancer. Appreciating PGE2-mediated immunomodulation is important in
understanding how tumors evade immune surveillance by re-educating infiltrating
inflammatory and immune cells to support tumorigenesis. Elucidation of the multiple and …