[HTML][HTML] CD161-expressing human T cells

JR Fergusson, VM Fleming, P Klenerman - Frontiers in immunology, 2011 - frontiersin.org
JR Fergusson, VM Fleming, P Klenerman
Frontiers in immunology, 2011frontiersin.org
Expression of the Natural Killer cell receptor CD161 has recently been identified on a subset
of T cells, including both CD4+ T helper and CD8+ T cells. Expression of this molecule
within the adult circulation is restricted to those T cells with a memory phenotype. However,
the distinct properties of these T cell populations is yet to be fully determined, although
expression of CD161 has been related to the secretion of interleukin-17, and therefore to a
type 17 phenotype. Recent studies have aimed to determine both the origin of these cells …
Expression of the Natural Killer cell receptor CD161 has recently been identified on a subset of T cells, including both CD4+ T helper and CD8+ T cells. Expression of this molecule within the adult circulation is restricted to those T cells with a memory phenotype. However, the distinct properties of these T cell populations is yet to be fully determined, although expression of CD161 has been related to the secretion of interleukin-17, and therefore to a type 17 phenotype. Recent studies have aimed to determine both the origin of these cells and the significance of CD161 expression as either a marker of specific cell types or as an effector and regulator of lymphocyte function, and hence to characterize the role of these CD161+ cells within a variety of human diseases in which they have been implicated.
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