Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas
M Bosic, M Kirchner, D Brasanac, J Leichsenring… - Pathology, 2018 - Elsevier
The genetic landscape of rare benign tumours and their malignant counterparts is still
largely unexplored. While recent work showed that mutant HRAS is present in subsets of
poromas and porocarcinomas, a more comprehensive genetic view on these rare adnexal
neoplasms is lacking. Using high-coverage next generation sequencing, we investigated the
mutational profile of 50 cancer-related genes in 12 cases (six poromas and six
porocarcinomas). Non-synonymous mutations were found in two-thirds of both poromas and …
largely unexplored. While recent work showed that mutant HRAS is present in subsets of
poromas and porocarcinomas, a more comprehensive genetic view on these rare adnexal
neoplasms is lacking. Using high-coverage next generation sequencing, we investigated the
mutational profile of 50 cancer-related genes in 12 cases (six poromas and six
porocarcinomas). Non-synonymous mutations were found in two-thirds of both poromas and …