[HTML][HTML] Human UTY (KDM6C) is a male-specific Nϵ-methyl lysyl demethylase
LJ Walport, RJ Hopkinson, M Vollmar… - Journal of Biological …, 2014 - ASBMB
The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate-and Fe (II)-dependent
oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that
catalyze demethylation of N ϵ-methylated histone 3 lysine 27 (H3K27), a mark important for
transcriptional repression. Despite reports stating that UTY (KDM6C) is inactive as a KDM,
we demonstrate by biochemical studies, employing MS and NMR, that UTY (KDM6C) is an
active KDM. Crystallographic analyses reveal that the UTY (KDM6C) active site is highly …
oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that
catalyze demethylation of N ϵ-methylated histone 3 lysine 27 (H3K27), a mark important for
transcriptional repression. Despite reports stating that UTY (KDM6C) is inactive as a KDM,
we demonstrate by biochemical studies, employing MS and NMR, that UTY (KDM6C) is an
active KDM. Crystallographic analyses reveal that the UTY (KDM6C) active site is highly …