What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?
AP Arnold, X Chen - Frontiers in neuroendocrinology, 2009 - Elsevier
The “four core genotypes”(FCG) model comprises mice in which sex chromosome
complement (XX vs. XY) is unrelated to the animal's gonadal sex. The four genotypes are XX
gonadal males or females, and XY gonadal males or females. The model allows one to
measure (1) the differences in phenotypes caused by sex chromosome complement (XX vs.
XY),(2) the differential effects of ovarian and testicular secretions, and (3) the interactive
effects of (1) and (2). Thus, the FCG model provides new information regarding the origins of …
complement (XX vs. XY) is unrelated to the animal's gonadal sex. The four genotypes are XX
gonadal males or females, and XY gonadal males or females. The model allows one to
measure (1) the differences in phenotypes caused by sex chromosome complement (XX vs.
XY),(2) the differential effects of ovarian and testicular secretions, and (3) the interactive
effects of (1) and (2). Thus, the FCG model provides new information regarding the origins of …