Colonic neutrophils in inflammatory bowel disease: double-edged swords of the innate immune system with protective and destructive capacity
IR Williams, CA Parkos - Gastroenterology, 2007 - gastrojournal.org
Several forms of active inflammatory bowel disease (IBD) feature the presence of a mixed
inflammatory infiltrate that includes neutrophils. A large influx of neutrophils can lead to the
formation of crypt abscesses, a characteristic histologic lesion resulting from activated
neutrophils transmigrating through the paracellular space separating enterocytes, breaching
tight junctions at the apical aspect of the lateral surface of epithelial cells, and accumulating
in the crypt lumen. Because such lesions and the presence of neutrophils in stool samples …
inflammatory infiltrate that includes neutrophils. A large influx of neutrophils can lead to the
formation of crypt abscesses, a characteristic histologic lesion resulting from activated
neutrophils transmigrating through the paracellular space separating enterocytes, breaching
tight junctions at the apical aspect of the lateral surface of epithelial cells, and accumulating
in the crypt lumen. Because such lesions and the presence of neutrophils in stool samples …